80%OF PATIENTS WHO LOSE WEIGHT WILL REGAIN IT. METABOLIC AND NEUROENDOCRINE ADAPTATIONS, INCLUDING HORMONE IMBALANCES AND CHANGES IN ENERGY EXPENDITURE, MAKE IT DIFFICULT FOR PATIENTS TO SUSTAIN WEIGHT LOSS. ONLY INDIVIDUALIZED MANAGEMENT PLANS HELP PATIENTS WITH LONG-TERM WEIGHT CONTROL; JOINT PHARMACEUTICAL ANDAND LIFESTYLE INTERVENTION, HEALTHY EATING, PHYSICAL ACTIVITY, BEHAVIORAL THERAPY.Multiple hormones like ghrelin, leptin and GLP-1play an important role in regulating appetite, and after weight loss, these hormones become unbalanced and even may not revert to their original levels.Weight loss causes changes in appetite regulation in hormones, resulting in an increase in appetite. These changes can persist for at least I year. Patients who receive the combined approach of pharmaceutical and lifestyle intervention may achieve greater weight loss. What it means is that those who lose weight and regain it, it is not their fault.But not all is lost! For successful weight maintenance, a multifacorial approach is necessary. According to the American Obesity Society a joint pharmaceutical and lifestyle intervention, healthy eating, physical activity and behavioral therapy.Therefore obesity should be recognized as a chronic disease!
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